TASK-2: a K2P K+ channel with complex regulation and diverse physiological functions
TASK-2 (K2P5.1) is a two-pore domain K+ channel belonging to the TALK subgroup of the K2P family of proteins. TASK-2 has been shown to be activated by extra- and intracellular alkalinisation. Extra- and intracellular pH-sensors reside at arginine 224 and lysine 245 and might affect separate selectiv...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-07-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00198/full |
| _version_ | 1818192964219830272 |
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| author | Luis Pablo Cid Hugo A Roa-Rojas Hugo A Roa-Rojas Maria Isabel eNiemeyer Wendy eGonzalez Masatake eAraki Kimi eAraki Francisco eSepulveda |
| author_facet | Luis Pablo Cid Hugo A Roa-Rojas Hugo A Roa-Rojas Maria Isabel eNiemeyer Wendy eGonzalez Masatake eAraki Kimi eAraki Francisco eSepulveda |
| author_sort | Luis Pablo Cid |
| collection | DOAJ |
| description | TASK-2 (K2P5.1) is a two-pore domain K+ channel belonging to the TALK subgroup of the K2P family of proteins. TASK-2 has been shown to be activated by extra- and intracellular alkalinisation. Extra- and intracellular pH-sensors reside at arginine 224 and lysine 245 and might affect separate selectivity filter and inner gates respectively. TASK-2 is modulated by changes in cell volume and a regulation by direct G-protein interaction has also been proposed. Activation by extracellular alkalinisation has been associated with a role of TASK-2 in kidney proximal tubule bicarbonate reabsorption, whilst intracellular pH-sensitivity might be the mechanism for its participation in central chemosensitive neurons. In addition to these functions TASK-2 has been proposed to play a part in apoptotic volume decrease in kidney cells and in volume regulation of glial cells and T-lymphocytes. TASK-2 is present in chondrocytes of hyaline cartilage, where it is proposed to play a central role in stabilizing the membrane potential. Additional sites of expression are dorsal root ganglion neurons, endocrine and exocrine pancreas and intestinal smooth muscle cells. TASK-2 has been associated with the regulation of proliferation of breast cancer cells and could become target for breast cancer therapeutics. Further work in native tissues and cells together with genetic modification will no doubt reveal the details of TASK-2 functions that we are only starting to suspect. |
| first_indexed | 2024-12-12T00:38:52Z |
| format | Article |
| id | doaj.art-786a7be601864207a1b219da415db3bd |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T00:38:52Z |
| publishDate | 2013-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-786a7be601864207a1b219da415db3bd2022-12-22T00:44:18ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2013-07-01410.3389/fphys.2013.0019853989TASK-2: a K2P K+ channel with complex regulation and diverse physiological functionsLuis Pablo Cid0Hugo A Roa-Rojas1Hugo A Roa-Rojas2Maria Isabel eNiemeyer3Wendy eGonzalez4Masatake eAraki5Kimi eAraki6Francisco eSepulveda7Centro de Estudios CientíficosCentro de Estudios CientíficosUniversidad Austral de ChileCentro de Estudios CientíficosUniversidad de TalcaKumamoto UniversityKumamoto UniversityCentro de Estudios CientíficosTASK-2 (K2P5.1) is a two-pore domain K+ channel belonging to the TALK subgroup of the K2P family of proteins. TASK-2 has been shown to be activated by extra- and intracellular alkalinisation. Extra- and intracellular pH-sensors reside at arginine 224 and lysine 245 and might affect separate selectivity filter and inner gates respectively. TASK-2 is modulated by changes in cell volume and a regulation by direct G-protein interaction has also been proposed. Activation by extracellular alkalinisation has been associated with a role of TASK-2 in kidney proximal tubule bicarbonate reabsorption, whilst intracellular pH-sensitivity might be the mechanism for its participation in central chemosensitive neurons. In addition to these functions TASK-2 has been proposed to play a part in apoptotic volume decrease in kidney cells and in volume regulation of glial cells and T-lymphocytes. TASK-2 is present in chondrocytes of hyaline cartilage, where it is proposed to play a central role in stabilizing the membrane potential. Additional sites of expression are dorsal root ganglion neurons, endocrine and exocrine pancreas and intestinal smooth muscle cells. TASK-2 has been associated with the regulation of proliferation of breast cancer cells and could become target for breast cancer therapeutics. Further work in native tissues and cells together with genetic modification will no doubt reveal the details of TASK-2 functions that we are only starting to suspect.http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00198/fullChondrocytesK2P channelsTASK-2 channelBicarbonate reabsorptionCentral chemoceptionCell volume regulation |
| spellingShingle | Luis Pablo Cid Hugo A Roa-Rojas Hugo A Roa-Rojas Maria Isabel eNiemeyer Wendy eGonzalez Masatake eAraki Kimi eAraki Francisco eSepulveda TASK-2: a K2P K+ channel with complex regulation and diverse physiological functions Frontiers in Physiology Chondrocytes K2P channels TASK-2 channel Bicarbonate reabsorption Central chemoception Cell volume regulation |
| title | TASK-2: a K2P K+ channel with complex regulation and diverse physiological functions |
| title_full | TASK-2: a K2P K+ channel with complex regulation and diverse physiological functions |
| title_fullStr | TASK-2: a K2P K+ channel with complex regulation and diverse physiological functions |
| title_full_unstemmed | TASK-2: a K2P K+ channel with complex regulation and diverse physiological functions |
| title_short | TASK-2: a K2P K+ channel with complex regulation and diverse physiological functions |
| title_sort | task 2 a k2p k channel with complex regulation and diverse physiological functions |
| topic | Chondrocytes K2P channels TASK-2 channel Bicarbonate reabsorption Central chemoception Cell volume regulation |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00198/full |
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