Development, Validation of LC-MS/MS Method and Determination of Pharmacokinetic Parameters of the Stroke Neuroprotectant Neurounina-1 in Beagle Dog Plasma After Intravenous Administration

Development, Validation of LC-MS/MS Method and Determination of Pharmacokinetic Parameters of the Stroke Neuroprotectant Neurounina-1 in Beagle Dog Plasma After Intravenous Administration

Neurounina-1 [chemical name: 7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1H-benzo[e][1,4]diazepin-2(3H)-one] is a new compound provided with relevant neuroprotective effect during stroke and in neonatal hypoxia by increasing the Na+/Ca2+ exchanger (NCX) isoforms NCX1 and NCX2 activity. This study sho...

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Bibliographic Details
Main Authors: Beatrice Severino, Angela Corvino, Ferdinando Fiorino, Francesco Frecentese, Elisa Perissutti, Giuseppe Caliendo, Vincenzo Santagada, Elisa Magli, Pasquale Molinaro, Giuseppe Pignataro, Lucio Annunziato, Natalícia J. Antunes, Julio Rojas-Moscoso, Noedi L. de Freitas, Gustavo D. Mendes, Gilberto De Nucci
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
neurounina-1
Na+/Ca2+ exchanger (NCX)
LC-MS/MS
beagle dog plasma
pharmacokinetics
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00432/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00432/full

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