Designing a potent multivalent epitope vaccine candidate against Orientia tsutsugamushi via reverse vaccinology technique - bioinformatics and immunoinformatic approach

Designing a potent multivalent epitope vaccine candidate against Orientia tsutsugamushi via reverse vaccinology technique - bioinformatics and immunoinformatic approach

Scrub typhus is a life-threatening, undifferentiated febrile illness caused by a gram-negative bacterium, Orientia tsutsugamushi. The bacterial strain is a global health concern that should be considered. Despite several years of effort for the development of an effective immunogenic vaccine, no suc...

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Bibliographic Details
Main Authors: Subhasmita Panda, Subrat Kumar Swain, Basanta Pravas Sahu, Soumya Ranjan Mahapatra, Jyotirmayee Dey, Rachita Sarangi, Anu Vinod Ranade, Namrata Mishra
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
multiplex vaccinology
scrub typhus
protein-protein docking
immune simulation
in-silico cloning
molecular dynamic simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1513245/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2025.1513245/full

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