Valproic acid exposure decreases neurogenic potential of outer radial glia in human brain organoids

Valproic acid exposure decreases neurogenic potential of outer radial glia in human brain organoids

Valproic acid (VPA) exposure during pregnancy leads to a higher risk of autism spectrum disorder (ASD) susceptibility in offspring. Human dorsal forebrain organoids were used to recapitulate course of cortical neurogenesis in the developing human brain. Combining morphological characterization with...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Zhenle Zang, Huachun Yin, Zhulin Du, Ruxin Xie, Ling Yang, Yun Cai, Liuyongwei Wang, Dandan Zhang, Xin Li, Tianyao Liu, Hong Gong, Junwei Gao, Hui Yang, Margaret Warner, Jan-Ake Gustafsson, Haiwei Xu, Xiaotang Fan
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: Frontiers Media S.A. 2022-11-01
Sarja:Frontiers in Molecular Neuroscience
Aiheet:
valproic acid
dorsal forebrain organoid
neurogenesis
autism spectrum disorder
outer radial glia
Linkit:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1023765/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.1023765/full

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