Valproic acid exposure decreases neurogenic potential of outer radial glia in human brain organoids

Valproic acid exposure decreases neurogenic potential of outer radial glia in human brain organoids

Valproic acid (VPA) exposure during pregnancy leads to a higher risk of autism spectrum disorder (ASD) susceptibility in offspring. Human dorsal forebrain organoids were used to recapitulate course of cortical neurogenesis in the developing human brain. Combining morphological characterization with...

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Bibliographic Details
Main Authors: Zhenle Zang, Huachun Yin, Zhulin Du, Ruxin Xie, Ling Yang, Yun Cai, Liuyongwei Wang, Dandan Zhang, Xin Li, Tianyao Liu, Hong Gong, Junwei Gao, Hui Yang, Margaret Warner, Jan-Ake Gustafsson, Haiwei Xu, Xiaotang Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
valproic acid
dorsal forebrain organoid
neurogenesis
autism spectrum disorder
outer radial glia
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1023765/full

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