Qinzhi Zhudan formula improves memory and alleviates neuroinflammation in vascular dementia rats partly by inhibiting the TNFR1-mediated TNF pathway

Qinzhi Zhudan formula improves memory and alleviates neuroinflammation in vascular dementia rats partly by inhibiting the TNFR1-mediated TNF pathway

Objective: The Qinzhi Zhudan formula (QZZD) exhibits a prominent therapeutic effect in the treatment of vascular dementia (VaD). This study combined a network pharmacology approach and experimental validation to identify the underlying biological mechanism of QZZD against VaD. Methods: Male Wistar r...

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Bibliographic Details
Main Authors: Shuling Liu, Fafeng Cheng, Beida Ren, Wenxiu Xu, Congai Chen, Chongyang Ma, Xiaole Zhang, Feifei Tang, Qingguo Wang, Xueqian Wang
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Journal of Traditional Chinese Medical Sciences
Subjects:
Vascular dementia
Neuroinflammation
Inflammatory cytokines
Microglia
TNF signaling Pathway
Network pharmacology
Online Access:http://www.sciencedirect.com/science/article/pii/S209575482200059X

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http://www.sciencedirect.com/science/article/pii/S209575482200059X

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