Loss of Response to Long-Term Infliximab Therapy in Children with Crohn’s Disease

Secondary loss of response (LoR) often precludes further use of infliximab in children with Crohn’s disease. Immunomodulators may reduce the incidence of LoR but their combination with infliximab presents safety concerns. We aimed to determine the long-term durability of infliximab response in paedi...

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Bibliographic Details
Main Authors: George Alex, Di Simpson, Anthony G. Catto-Smith, Oliver Gouldthorpe
Format: Article
Language:English
Published: MDPI AG 2013-10-01
Series:Pharmaceuticals
Subjects:
Online Access:http://www.mdpi.com/1424-8247/6/10/1322