Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a <i>de novo</i> DNA Methyltransferase

Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a <i>de novo</i> DNA Methyltransferase

DNA damage and base excision repair (BER) are actively involved in the modulation of DNA methylation and demethylation. However, the underlying molecular mechanisms remain unclear. In this study, we seek to understand the mechanisms by exploring the effects of oxidative DNA damage on the DNA methyla...

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Bibliographic Details
Main Authors: Zhongliang Jiang, Yanhao Lai, Jill M. Beaver, Pawlos S. Tsegay, Ming-Lang Zhao, Julie K. Horton, Marco Zamora, Hayley L. Rein, Frank Miralles, Mohammad Shaver, Joshua D. Hutcheson, Irina Agoulnik, Samuel H. Wilson, Yuan Liu
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
oxidative dna damage
dna polymerase β
dna methyltransferase 3b
brca1
base excision repair
dna methylation
<i>de novo</i> dna methylation
Online Access:https://www.mdpi.com/2073-4409/9/1/225

Internet

https://www.mdpi.com/2073-4409/9/1/225

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