ALPL regulates pro-angiogenic capacity of mesenchymal stem cells through ATP-P2X7 axis controlled exosomes secretion

ALPL regulates pro-angiogenic capacity of mesenchymal stem cells through ATP-P2X7 axis controlled exosomes secretion

Abstract Background Early-onset bone dysplasia is a common manifestation of hypophosphatasia (HPP), an autosomal inherited disease caused by ALPL mutation. ALPL ablation induces prototypical premature bone ageing characteristics, resulting in impaired osteogenic differentiation capacity of human bon...

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Bibliographic Details
Main Authors: Jiayi Dong, Wanmin Zhao, Jiangdong Zhao, Ji Chen, Ping Liu, Xueni Zheng, Dehua Li, Yang Xue, Hongzhi Zhou
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Nanobiotechnology
Subjects:
Hypophosphatasia
Angiogenesis
BMMSCs
Exosomes
ALPL
P2X7
Online Access:https://doi.org/10.1186/s12951-024-02396-6

Internet

https://doi.org/10.1186/s12951-024-02396-6

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