Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

Given the recent Zika virus (ZIKV) epidemic, development of an effective vaccine is of high importance. Here, the authors use a licensed live-attenuated flavivirus vaccine backbone to develop a ZIKV vaccine and determine immunogenicity, safety and protection profiles in different animal models.

Bibliographic Details
Main Authors: Xiao-Feng Li, Hao-Long Dong, Hong-Jiang Wang, Xing-Yao Huang, Ye-Feng Qiu, Xue Ji, Qing Ye, Chunfeng Li, Yang Liu, Yong-Qiang Deng, Tao Jiang, Gong Cheng, Fu-Chun Zhang, Andrew D. Davidson, Ya-Jun Song, Pei-Yong Shi, Cheng-Feng Qin
Format: Article
Language:English
Published: Nature Portfolio 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-02975-w

Internet

https://doi.org/10.1038/s41467-018-02975-w

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