A semi-automated microscopic image analysis method for scoring Ki-67 nuclear immunostaining

A semi-automated microscopic image analysis method for scoring Ki-67 nuclear immunostaining

Nuclear proliferation marker MIB-1 (Ki-67) immunohistochemistry (IHC) is used to examine tumor cell proliferation. However, the diagnostic or prognostic value of the Ki-67 nuclear staining intensity and location, defined as nuclear gradient (NG), has not been assessed. This study examined the potent...

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Bibliographic Details
Main Authors: S.M. Fernezlian, C.M. Baldavira, M.L.F. de Souza, C. Farhat, A.F. de Vilhena, J.C.N. Pereira, J.R.M. de Campos, T. Takagaki, M.L. Balancin, A.M. Ab'Saber, V.L. Capelozzi
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2023-11-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Pulmonary typical carcinoid tumor
Chromatin gradient
Cell cycle
Image analysis
Prognosis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100689&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2023000100689&lng=en&tlng=en

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