Synthesis, in-silico studies, and biological evaluation of some novel 3-thiazolyl-indoles as CDK2–inhibitors

Synthesis, in-silico studies, and biological evaluation of some novel 3-thiazolyl-indoles as CDK2–inhibitors

The essential enzyme cyclin-dependent kinase 2 (CDK2) is a promising target for anticancer drug development due to its pivotal role in regulating the cell cycle. This study aimed to synthesize novel 3-thiazolyl-indole derivatives and assess their ability to inhibit CDK2 using molecular docking analy...

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Bibliographic Details
Main Authors: Sobhi M. Gomha, Magdi E.A. Zaki, Deepika Maliwal, Raghuvir R.S. Pissurlenkar, Mohamed S. Ibrahim, Maher Fathalla, Ahmed M. Hussein
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Results in Chemistry
Subjects:
Indoles
Thiazoles
Thiosemicarbazones
Hydrazonoyl halides
Anticancer
Molecular Docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715623004484

Internet

http://www.sciencedirect.com/science/article/pii/S2211715623004484

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