Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors

Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors

Abstract Background Colorectal cancer (CRC) ranks as the second-leading cause of cancer-related death worldwide with metastases being the main cause of cancer-related death. Here, we investigated the genomic and transcriptomic alterations in matching adjacent normal tissues, primary tumors, and meta...

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Bibliographic Details
Main Authors: Rui Wang, Jingyun Li, Xin Zhou, Yunuo Mao, Wendong Wang, Shuai Gao, Wei Wang, Yuan Gao, Kexuan Chen, Shuntai Yu, Xinglong Wu, Lu Wen, Hao Ge, Wei Fu, Fuchou Tang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Genome Medicine
Subjects:
Metastatic colorectal cancer
Single-cell transcriptome profiling
Lineage tracing
Genotype-phenotype relationship
Mitochondrial mutations
Patient-derived organoids
Online Access:https://doi.org/10.1186/s13073-022-01093-z

Internet

https://doi.org/10.1186/s13073-022-01093-z

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