Actively Targeted and Redox Responsive Delivery of Anticancer Drug by Chitosan Nanoparticles

Actively Targeted and Redox Responsive Delivery of Anticancer Drug by Chitosan Nanoparticles

The clinical efficacy of methotrexate (MTX) is limited by its poor water solubility, its low bioavailability, and the development of resistance in cancer cells. Herein, we developed novel folate redox-responsive chitosan (FTC) nanoparticles for intracellular MTX delivery. <span style="font-v...

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Bibliographic Details
Main Authors: Elisabetta Mazzotta, Selene De Benedittis, Antonio Qualtieri, Rita Muzzalupo
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Pharmaceutics
Subjects:
redox-responsive
folate-targeting
chitosan nanoparticles
methotrexate
intracellular drug release
Online Access:https://www.mdpi.com/1999-4923/12/1/26

Internet

https://www.mdpi.com/1999-4923/12/1/26

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