TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner

TDP43 interacts with MLH1 and MSH6 proteins in a DNA damage-inducible manner

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the motor neuron. One aspect of the neuropathology involved in ALS includes increased genomic damage and impaired DNA repair capability. The TAR-DNA binding protein 43 (TDP43) has been associated with both...

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Bibliographic Details
Main Authors: Vincent E. Provasek, Manohar Kodavati, Brandon Kim, Joy Mitra, Muralidhar L. Hegde
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Molecular Brain
Subjects:
TDP-43
DNA mismatch repair (MMR)
DNA double-strand breaks (DSBs)
Neurodegeneration
Amyotrophic lateral sclerosis (ALS)
Co-immunoprecipitation (CoIP)
Online Access:https://doi.org/10.1186/s13041-024-01108-3

Internet

https://doi.org/10.1186/s13041-024-01108-3

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