Uric acid–driven NLRP3 inflammasome activation triggers lens epithelial cell senescence and cataract formation
Abstract Excessive uric acid (UA) is associated with age-related cataract. A previous study showed that a high UA level in the aqueous humor stimulated the senescence of lens epithelial cells (LECs), leading to cataract progression. To better understand the underlying mechanisms, we investigated UA-...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2024-03-01
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Series: | Cell Death Discovery |
Online Access: | https://doi.org/10.1038/s41420-024-01900-z |