Uric acid–driven NLRP3 inflammasome activation triggers lens epithelial cell senescence and cataract formation

Abstract Excessive uric acid (UA) is associated with age-related cataract. A previous study showed that a high UA level in the aqueous humor stimulated the senescence of lens epithelial cells (LECs), leading to cataract progression. To better understand the underlying mechanisms, we investigated UA-...

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Bibliographic Details
Main Authors: Hong Liang Lin, Sheng Wang, Kota Sato, Yu Qiao Zhang, Bei Ting He, Jing Xu, Toru Nakazawa, Yong Jie Qin, Hong Yang Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2024-03-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-01900-z