Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling

Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling

Background: Despite significant progress in clinical management, colorectal cancer (CRC) remains the third most common cause of cancer-related deaths. A positive association between PYCR2 (pyrroline-5-carboxylate reductase-2), a terminal enzyme of proline metabolism, and CRC aggressiveness was recen...

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Bibliographic Details
Main Authors: Raju Lama Tamang, Balawant Kumar, Sagar M. Patel, Ishwor Thapa, Alshomrani Ahmad, Vikas Kumar, Rizwan Ahmad, Donald F. Becker, Dundy (Kiran) Bastola, Punita Dhawan, Amar B. Singh
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
pyrroline 5 carboxylate reductases (PYCRs)
colorectal cancer (CRC)
proline metabolism
cancer progression
MASTL
Wnt signaling
Online Access:https://www.mdpi.com/2073-4409/12/14/1883

Internet

https://www.mdpi.com/2073-4409/12/14/1883

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