Identification of a small-molecule RPL11 mimetic that inhibits tumor growth by targeting MDM2-p53 pathway

Identification of a small-molecule RPL11 mimetic that inhibits tumor growth by targeting MDM2-p53 pathway

Abstract Background Targeting ribosome biogenesis to activate p53 has recently emerged as a therapeutic strategy in human cancer. Among various ribosomal proteins, RPL11 centralizes the nucleolar stress-sensing pathway by binding MDM2, leading to MDM2 inactivation and p53 activation. Therefore, the...

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Bibliographic Details
Main Authors: Bingwu Wang, Jian Gao, Zhongjun Zhao, Xuefei Zhong, Hao Cui, Hui Hou, Yanping Zhang, Junnian Zheng, Jiehui Di, Yong Liu
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Molecular Medicine
Subjects:
S9
RPL11-MDM2-p53 pathway
Cell proliferation
Cell cycle arrest
Apoptosis
Online Access:https://doi.org/10.1186/s10020-022-00537-x

Internet

https://doi.org/10.1186/s10020-022-00537-x

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