Lynch syndrome cancer vaccines: A roadmap for the development of precision immunoprevention strategies

Lynch syndrome cancer vaccines: A roadmap for the development of precision immunoprevention strategies

Hereditary cancer syndromes (HCS) account for 5~10% of all cancer diagnosis. Lynch syndrome (LS) is one of the most common HCS, caused by germline mutations in the DNA mismatch repair (MMR) genes. Even with prospective cancer surveillance, LS is associated with up to 50% lifetime risk of colorectal,...

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Bibliographic Details
Main Authors: Shizuko Sei, Aysel Ahadova, Derin B. Keskin, Lena Bohaumilitzky, Johannes Gebert, Magnus von Knebel Doeberitz, Steven M. Lipkin, Matthias Kloor
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Oncology
Subjects:
lynch syndrome
DNA mismatch repair deficiency
microsatellite instability
frameshift mutations
tumor neoantigens
cancer vaccines
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1147590/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1147590/full

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