Deoxyribonucleic Acid 5-Hydroxymethylation in Cell-Free Deoxyribonucleic Acid, a Novel Cancer Biomarker in the Era of Precision Medicine

Deoxyribonucleic Acid 5-Hydroxymethylation in Cell-Free Deoxyribonucleic Acid, a Novel Cancer Biomarker in the Era of Precision Medicine

Aberrant methylation has been regarded as a hallmark of cancer. 5-hydroxymethylcytosine (5hmC) is recently identified as the ten-eleven translocase (ten-eleven translocase)-mediated oxidized form of 5-methylcytosine, which plays a substantial role in DNA demethylation. Cell-free DNA has been introdu...

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Bibliographic Details
Main Authors: Ling Xu, Yixin Zhou, Lijie Chen, Abdul Saad Bissessur, Jida Chen, Misha Mao, Siwei Ju, Lini Chen, Cong Chen, Zhaoqin Li, Xun Zhang, Fei Chen, Feilin Cao, Linbo Wang, Qinchuan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
5-hydroxymethylcytosine
cell-free DNA
ten-eleven translocase
liquid biopsy
cancer biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.744990/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.744990/full

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