Reversible Platelet Integrin αIIbβ3 Activation and Thrombus Instability

Reversible Platelet Integrin αIIbβ3 Activation and Thrombus Instability

Integrin αIIbβ3 activation is essential for platelet aggregation and, accordingly, for hemostasis and arterial thrombosis. The αIIbβ3 integrin is highly expressed on platelets and requires an activation step for binding to fibrinogen, fibrin or von Willebrand factor (VWF). A current model assumes th...

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Bibliographic Details
Main Authors: Jinmi Zou, Frauke Swieringa, Bas de Laat, Philip G. de Groot, Mark Roest, Johan W. M. Heemskerk
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
ADP
collagen
fibrinogen
integrin
platelets
thrombin
Online Access:https://www.mdpi.com/1422-0067/23/20/12512

Internet

https://www.mdpi.com/1422-0067/23/20/12512

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