Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations

Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations

Abstract Background Type 2 diabetes (T2D) is a heterogeneous and polygenic disease. Previous studies have leveraged the highly polygenic and pleiotropic nature of T2D variants to partition the heterogeneity of T2D, in order to stratify patient risk and gain mechanistic insight. We expanded on these...

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Bibliographic Details
Main Authors: Samuel Ghatan, Jeroen van Rooij, Mandy van Hoek, Cindy G. Boer, Janine F. Felix, Maryam Kavousi, Vincent W. Jaddoe, Eric J. G. Sijbrands, Carolina Medina-Gomez, Fernando Rivadeneira, Ling Oei
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Genome Medicine
Subjects:
Polygenic risk score
Type 2 diabetes
Colocalization
Clustering
Personalized medicine
Online Access:https://doi.org/10.1186/s13073-023-01255-7

Internet

https://doi.org/10.1186/s13073-023-01255-7

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