Mpox multi-antigen mRNA vaccine candidates by a simplified manufacturing strategy afford efficient protection against lethal orthopoxvirus challenge

Mpox multi-antigen mRNA vaccine candidates by a simplified manufacturing strategy afford efficient protection against lethal orthopoxvirus challenge

ABSTRACTCurrent unprecedented mpox outbreaks in non-endemic regions represent a global public health concern. Although two live-attenuated vaccinia virus (VACV)-based vaccines have been urgently approved for people at high risk for mpox, a safer and more effective vaccine that can be available for t...

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Bibliographic Details
Main Authors: Jiawei Zeng, Yao Li, Linrui Jiang, Ling Luo, Yue Wang, Hao Wang, Xiaonan Han, Jian Zhao, Guanglei Gu, Min Fang, Qingrui Huang, Jinghua Yan
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
Mpox
mRNA vaccine
multi-antigen
VACV challenge
simplified manufacturing
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2204151

Internet

https://www.tandfonline.com/doi/10.1080/22221751.2023.2204151

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