Efficacy of rupatadine in reducing the incidence of dengue haemorrhagic fever in patients with acute dengue: A randomised, double blind, placebo-controlled trial.

Efficacy of rupatadine in reducing the incidence of dengue haemorrhagic fever in patients with acute dengue: A randomised, double blind, placebo-controlled trial.

<h4>Background</h4>Rupatadine was previously shown to reduce endothelial dysfunction in vitro, reduced vascular leak in dengue mouse models and to reduce the extent of pleural effusions and thrombocytopenia in patients with acute dengue. Therefore, we sought to determine the efficacy of...

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Bibliographic Details
Main Authors: Gathsaurie Neelika Malavige, Chandima Jeewandara, Ananda Wijewickrama, Dumni Gunasinghe, Sameera D Mahapatuna, Chathurika Gangani, Vimalahan Vimalachandran, Geethal Jayarathna, Yashoda Perera, Chandanie Wanigatunga, Harsha Dissanayake, Shamini Prathapan, Eranga Narangoda, Damayanthi Idampitiya, Laksiri Gomes, Samurdhi Wickramanayake, Pramodth Sahabandu, Graham S Ogg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-06-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0010123

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https://doi.org/10.1371/journal.pntd.0010123

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