Structural basis for the ligand promiscuity of the neofunctionalized, carotenoid-binding fasciclin domain protein AstaP

Structural basis for the ligand promiscuity of the neofunctionalized, carotenoid-binding fasciclin domain protein AstaP

Abstract Fasciclins (FAS1) are ancient adhesion protein domains with no common small ligand binding reported. A unique microalgal FAS1-containing astaxanthin (AXT)-binding protein (AstaP) binds a broad repertoire of carotenoids by a largely unknown mechanism. Here, we explain the ligand promiscuity...

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Bibliographic Details
Main Authors: Fedor D. Kornilov, Yury B. Slonimskiy, Daria A. Lunegova, Nikita A. Egorkin, Anna G. Savitskaya, Sergey Yu. Kleymenov, Eugene G. Maksimov, Sergey A. Goncharuk, Konstantin S. Mineev, Nikolai N. Sluchanko
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04832-z

Internet

https://doi.org/10.1038/s42003-023-04832-z

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