Targeting aberrant glycosylation to modulate microglial response and improve cognition in models of Alzheimer’s disease

Targeting aberrant glycosylation to modulate microglial response and improve cognition in models of Alzheimer’s disease

Altered glycosylation profiles have been correlated with potential drug targets in various diseases, including Alzheimer’s disease (AD). In this area, the linkage between bisecting N-acetylglucosamine (GlcNAc), a product of N-acetylglucosaminyltransferase III (GnT-III), and AD has been recognized, h...

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Bibliographic Details
Main Authors: Yue Wang, Yixuan Du, Hongfei Huang, Yiming Cao, Kemeng Pan, Yueqian Zhou, Jiawei He, Wenbing Yao, Song Chen, Xiangdong Gao
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Pharmacological Research
Subjects:
Alzheimer’s disease
Bisecting glycosylation
N-acetylglucosaminyltransferase III
Microglia
Intercellular adhesion molecule-1
Online Access:http://www.sciencedirect.com/science/article/pii/S104366182400077X

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http://www.sciencedirect.com/science/article/pii/S104366182400077X

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