Exploring the dynamics of adult Axin2 cell lineage integration into dentate gyrus granule neurons

Exploring the dynamics of adult Axin2 cell lineage integration into dentate gyrus granule neurons

The Wnt pathway plays critical roles in neurogenesis. The expression of Axin2 is induced by Wnt/β-catenin signaling, making this gene a reliable indicator of canonical Wnt activity. We employed pulse-chase genetic lineage tracing with the Axin2-CreERT2 allele to follow the fate of Axin2+ lineage in...

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Bibliographic Details
Main Authors: Khadijeh A. Sharifi, Faraz Farzad, Sauson Soldozy, Matthew R. DeWitt, Richard J. Price, Jason Sheehan, M. Yashar S. Kalani, Petr Tvrdik
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Neuroscience
Subjects:
adult neurogenesis
dentate gyrus
Wnt signaling
Axin2 cell lineage
focused ultrasound
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1353142/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2024.1353142/full

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