Identification and Characterization of Key Differentially Expressed Genes Associated With Metronomic Dosing of Topotecan in Human Prostate Cancer

Identification and Characterization of Key Differentially Expressed Genes Associated With Metronomic Dosing of Topotecan in Human Prostate Cancer

Repetitive, low-dose (metronomic; METRO) drug administration of some anticancer agents can overcome drug resistance and increase drug efficacy in many cancers, but the mechanisms are not understood fully. Previously, we showed that METRO dosing of topotecan (TOPO) is more effective than conventional...

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Bibliographic Details
Main Authors: Taraswi Mitra Ghosh, Jason White, Joshua Davis, Suman Mazumder, Teeratas Kansom, Elena Skarupa, Grafton S. Barnett, Gary A. Piazza, R. Curtis Bird, Amit K. Mitra, Clayton Yates, Brian S. Cummings, Robert D. Arnold
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Pharmacology
Subjects:
topotecan
metronomic
prostate cancer
mCRPC
transcriptomics
RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.736951/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.736951/full

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