A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Abstract Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's disease (HD) is characterized by the intracellular accumulation of mutant huntingtin (mHTT) that can be soluble and aggregated in the ce...

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Bibliographic Details
Main Authors: Caijuan Li, Yingqi Lin, Yizhi Chen, Xichen Song, Xiao Zheng, Jiawei Li, Jun He, Xiusheng Chen, Chunhui Huang, Wei Wang, Jianhao Wu, Jiaxi Wu, Jiale Gao, Zhuchi Tu, Xiao‐Jiang Li, Sen Yan, Shihua Li
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Advanced Science
Subjects:
HD KI‐140Q mice
intravenous injection
lysosome
mini‐intrabody
mutant huntingtin
SM3
Online Access:https://doi.org/10.1002/advs.202301120

Internet

https://doi.org/10.1002/advs.202301120

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