Hypertrophic cardiomyopathy is characterized by alterations of the mitochondrial calcium uniporter complex proteins: insights from patients with aortic valve stenosis versus hypertrophic obstructive cardiomyopathy

Hypertrophic cardiomyopathy is characterized by alterations of the mitochondrial calcium uniporter complex proteins: insights from patients with aortic valve stenosis versus hypertrophic obstructive cardiomyopathy

Introduction: Hypertrophies of the cardiac septum are caused either by aortic valve stenosis (AVS) or by congenital hypertrophic obstructive cardiomyopathy (HOCM). As they induce cardiac remodeling, these cardiac pathologies may promote an arrhythmogenic substrate with associated malignant ventricul...

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Bibliographic Details
Main Authors: Vera Paar, Michael Haslinger, Philipp Krombholz-Reindl, Stefan Pittner, Matthias Neuner, Peter Jirak, Tobias Kolbitsch, Bernd Minnich, Falk Schrödl, Alexandra Kaser-Eichberger, Kristen Kopp, Andreas Koller, Clemens Steinwender, Michael Lichtenauer, Fabio C. Monticelli, Rainald Seitelberger, Uta C. Hoppe, Christian Dinges, Lukas J. Motloch
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
left ventricular hypertrophy
aortic valve stenosis
hypertrophic obstructive cardiomyopathy
fibrosis
calcium
mitochondria
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1264216/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1264216/full

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