The emerging roles of CDK12 in tumorigenesis
Abstract Cyclin-dependent kinases (CDKs) are key regulators of both cell cycle progression and transcription. Since dysregulation of CDKs is a frequently occurring event driving tumorigenesis, CDKs have been tested extensively as targets for cancer therapy. Cyclin-dependent kinase 12 (CDK12) is a tr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2017-10-01
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| Series: | Cell Division |
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| Online Access: | http://link.springer.com/article/10.1186/s13008-017-0033-x |
| _version_ | 1819047561486401536 |
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| author | Hana Paculová Jiří Kohoutek |
| author_facet | Hana Paculová Jiří Kohoutek |
| author_sort | Hana Paculová |
| collection | DOAJ |
| description | Abstract Cyclin-dependent kinases (CDKs) are key regulators of both cell cycle progression and transcription. Since dysregulation of CDKs is a frequently occurring event driving tumorigenesis, CDKs have been tested extensively as targets for cancer therapy. Cyclin-dependent kinase 12 (CDK12) is a transcription-associated kinase which participates in various cellular processes, including DNA damage response, development and cellular differentiation, as well as splicing and pre-mRNA processing. CDK12 mutations and amplification have been recently reported in different types of malignancies, including loss-of-function mutations in high-grade serous ovarian carcinomas, and that has led to assumption that CDK12 is a tumor suppressor. On the contrary, CDK12 overexpression in other tumors suggests the possibility that CDK12 has oncogenic properties, similarly to other transcription-associated kinases. In this review, we discuss current knowledge concerning the role of CDK12 in ovarian and breast tumorigenesis and the potential for chemical inhibitors of CDK12 in future cancer treatment. |
| first_indexed | 2024-12-21T11:02:19Z |
| format | Article |
| id | doaj.art-78c5bf2482ed4dc58ca78dd46d4dd1f7 |
| institution | Directory Open Access Journal |
| issn | 1747-1028 |
| language | English |
| last_indexed | 2024-12-21T11:02:19Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Division |
| spelling | doaj.art-78c5bf2482ed4dc58ca78dd46d4dd1f72022-12-21T19:06:19ZengBMCCell Division1747-10282017-10-0112111010.1186/s13008-017-0033-xThe emerging roles of CDK12 in tumorigenesisHana Paculová0Jiří Kohoutek1Department of Chemistry and Toxicology, Veterinary Research InstituteDepartment of Chemistry and Toxicology, Veterinary Research InstituteAbstract Cyclin-dependent kinases (CDKs) are key regulators of both cell cycle progression and transcription. Since dysregulation of CDKs is a frequently occurring event driving tumorigenesis, CDKs have been tested extensively as targets for cancer therapy. Cyclin-dependent kinase 12 (CDK12) is a transcription-associated kinase which participates in various cellular processes, including DNA damage response, development and cellular differentiation, as well as splicing and pre-mRNA processing. CDK12 mutations and amplification have been recently reported in different types of malignancies, including loss-of-function mutations in high-grade serous ovarian carcinomas, and that has led to assumption that CDK12 is a tumor suppressor. On the contrary, CDK12 overexpression in other tumors suggests the possibility that CDK12 has oncogenic properties, similarly to other transcription-associated kinases. In this review, we discuss current knowledge concerning the role of CDK12 in ovarian and breast tumorigenesis and the potential for chemical inhibitors of CDK12 in future cancer treatment.http://link.springer.com/article/10.1186/s13008-017-0033-xCDK12RNA pol IISuppressorOncogeneDinaciclibTHZ531 |
| spellingShingle | Hana Paculová Jiří Kohoutek The emerging roles of CDK12 in tumorigenesis Cell Division CDK12 RNA pol II Suppressor Oncogene Dinaciclib THZ531 |
| title | The emerging roles of CDK12 in tumorigenesis |
| title_full | The emerging roles of CDK12 in tumorigenesis |
| title_fullStr | The emerging roles of CDK12 in tumorigenesis |
| title_full_unstemmed | The emerging roles of CDK12 in tumorigenesis |
| title_short | The emerging roles of CDK12 in tumorigenesis |
| title_sort | emerging roles of cdk12 in tumorigenesis |
| topic | CDK12 RNA pol II Suppressor Oncogene Dinaciclib THZ531 |
| url | http://link.springer.com/article/10.1186/s13008-017-0033-x |
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