The effect of sickle cell genotype on the pharmacokinetic properties of artemether-lumefantrine in Tanzanian children

The effect of sickle cell genotype on the pharmacokinetic properties of artemether-lumefantrine in Tanzanian children

Since there are inconsistent data relating to the effect of haemoglobinopathies on disposition of artemisinin antimalarial combination therapy, and none in sickle cell trait (SCT) or sickle cell disease (SCD), the aim of this study was to characterize the pharmacokinetic properties of artemether-lum...

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Bibliographic Details
Main Authors: Sri Riyati Sugiarto, George M. Bwire, Brioni R. Moore, Madhu Page-Sharp, Laurens Manning, Kevin T. Batty, Omary M.S. Minzi, Billy Ngasala, Timothy M.E. Davis, Julie Makani, Sam Salman
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Sickle cell disease
Sickle cell trait
Artemether
Dihydroartemisinin
Lumefantrine
Desbutyl-lumefantrine
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320722000082

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http://www.sciencedirect.com/science/article/pii/S2211320722000082

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