A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing

A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing

The origin of Fc receptor-based phagocytosis is unknown, although plasma lipid redistribution after solid structure binding induces similar phagocytic signaling. Here, Mu et al. show that PIP2 accumulation from plasma membrane deformation recruits Moesin to trigger receptor-independent phagocytosis.

Bibliographic Details
Main Authors: Libing Mu, Zhongyuan Tu, Lin Miao, Hefei Ruan, Ning Kang, Yongzhen Hei, Jiahuan Chen, Wei Wei, Fangling Gong, Bingjie Wang, Yanan Du, Guanghui Ma, Matthias W. Amerein, Tie Xia, Yan Shi
Format: Article
Language:English
Published: Nature Portfolio 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06744-7

Internet

https://doi.org/10.1038/s41467-018-06744-7

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