Metformin reduces the cellular DNA repair capacity and enhances the effect of curcumin on the induction of apoptosis in AGS gastric cancer cells

Metformin reduces the cellular DNA repair capacity and enhances the effect of curcumin on the induction of apoptosis in AGS gastric cancer cells

Abstract Background Cancer results from the accumulation of mutations in critical genes, such as DNA repair genes. But these genes are a double-edged sword, because the basis of current cancer treatment is DNA damage from chemotherapy and radiation, and the repair system can slow the healing process...

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Bibliographic Details
Main Authors: Ehsan Zarei, Iraj Saadat
Format: Article
Language:English
Published: SpringerOpen 2023-10-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Metformin
Curcumin
DNA repair gene
Apoptosis
Online Access:https://doi.org/10.1186/s43042-023-00445-7

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