Casein Kinase 1 Phosphomimetic Mutations Negatively Impact Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived Cardiomyocytes

Casein Kinase 1 Phosphomimetic Mutations Negatively Impact Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived Cardiomyocytes

The transplantation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has shown promise in preclinical models of myocardial infarction, but graft myocardium exhibits incomplete host–graft electromechanical integration and a propensity for pro-arrhythmic behavior. Perhaps contributing...

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Bibliographic Details
Main Authors: Rasha Al-attar, Joseph Jargstorf, Rocco Romagnuolo, Mariam Jouni, Faisal J. Alibhai, Paul D. Lampe, Joell L. Solan, Michael A. Laflamme
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Biomolecules
Subjects:
connexin 43
gap junctions
human pluripotent stem cell-derived cardiomyocytes
phosphorylation
Online Access:https://www.mdpi.com/2218-273X/14/1/61

Internet

https://www.mdpi.com/2218-273X/14/1/61

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