Prdm15 acts upstream of Wnt4 signaling in anterior neural development of Xenopus laevis

Prdm15 acts upstream of Wnt4 signaling in anterior neural development of Xenopus laevis

Mutations in PRDM15 lead to a syndromic form of holoprosencephaly (HPE) known as the Galloway–Mowat syndrome (GAMOS). While a connection between PRDM15, a zinc finger transcription factor, and WNT/PCP signaling has been established, there is a critical need to delve deeper into their contributions t...

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Bibliographic Details
Main Authors: Ernestine Saumweber, Slim Mzoughi, Arin Khadra, Anja Werberger, Sven Schumann, Ernesto Guccione, Michael J. Schmeisser, Susanne J. Kühl
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Prdm15
GAMOS
HPE
disease modeling
Xenopus laevis
Wnt signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1316048/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2024.1316048/full

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