A novel single gene deletion (-αMAL3.5) giving rise to silent α thalassemia carrier removing the entire HBA2 gene observed in two Chinese patients with Hb H disease: case report of two probands

A novel single gene deletion (-αMAL3.5) giving rise to silent α thalassemia carrier removing the entire HBA2 gene observed in two Chinese patients with Hb H disease: case report of two probands

We report a novel deletion at the <em>HBA2</em> presented with Hb H disease in two Malaysian- Chinese patients. The two unrelated probands were diagnosed with Hb H disease in a primary hematological screening for thalassemia. Results from routine molecular analysis with gap-polymerase ch...

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Bibliographic Details
Main Authors: Faidatul Syazlin Abdul Hamid, Rahimah Ahmad, Mohamed Saleem, Nur Aisyah Aziz, Syahira Lazira Omar, Siti Hida Hajira Mohamad Arif, Jameela Sathar, Zubaidah Zakaria
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Thalassemia Reports
Subjects:
α-thalassemia
Hb H disease
thalassemia intermedia
3.5 kb deletion
single gene deletion.
Online Access:http://www.pagepressjournals.org/index.php/thal/article/view/4675

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http://www.pagepressjournals.org/index.php/thal/article/view/4675

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