Post‐Myocardial Infarction T‐tubules Form Enlarged Branched Structures With Dysregulation of Junctophilin‐2 and Bridging Integrator 1 (BIN‐1)

Post‐Myocardial Infarction T‐tubules Form Enlarged Branched Structures With Dysregulation of Junctophilin‐2 and Bridging Integrator 1 (BIN‐1)

BackgroundHeart failure is a common secondary complication following a myocardial infarction (MI), characterized by impaired cardiac contraction and t‐tubule (t‐t) loss. However, post‐MI nano‐scale morphological changes to the remaining t‐ts are poorly understood. Method and ResultsWe utilized a por...

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Bibliographic Details
Main Authors: Christian Pinali, Nadim Malik, J. Bernard Davenport, Laurence J. Allan, Lucy Murfitt, Mohammad M. Iqbal, Mark R. Boyett, Elizabeth J. Wright, Rachel Walker, Yu Zhang, Halina Dobryznski, Cathy M. Holt, Ashraf Kitmitto
Format: Article
Language:English
Published: Wiley 2017-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
3D electron microscopy
bridging integrator 1 protein
Eps 15 homology domain protein
heart failure
junctophilin‐2
myocardial infarction
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.116.004834

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.116.004834

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