Posttranslational modification and beyond: interplay between histone deacetylase 6 and heat-shock protein 90

Posttranslational modification and beyond: interplay between histone deacetylase 6 and heat-shock protein 90

Abstract Posttranslational modification (PTM) and regulation of protein stability are crucial to various biological processes. Histone deacetylase 6 (HDAC6), a unique histone deacetylase with two functional catalytic domains (DD1 and DD2) and a ZnF-UBP domain (ubiquitin binding domain, BUZ), regulat...

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Bibliographic Details
Main Authors: Ping Liu, Ji Xiao, Yiliang Wang, Xiaowei Song, Lianzhou Huang, Zhe Ren, Kaio Kitazato, Yifei Wang
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Molecular Medicine
Subjects:
HDAC6
Hsp90
Client proteins
Acetylation
Drug development
Online Access:https://doi.org/10.1186/s10020-021-00375-3

Internet

https://doi.org/10.1186/s10020-021-00375-3

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