Histone Methylation Inhibitor DZNep Ameliorated the Renal Ischemia-Reperfusion Injury via Inhibiting TIM-1 Mediated T Cell Activation

Histone Methylation Inhibitor DZNep Ameliorated the Renal Ischemia-Reperfusion Injury via Inhibiting TIM-1 Mediated T Cell Activation

Renal ischemia-reperfusion injury (IRI) after renal transplantation often leads to the loss of kidney graft function. However, there is still a lack of efficient regimens to prevent or alleviate renal IRI. Our study focused on the renoprotective effect of 3-Deazaneplanocin A (DZNep), which is a hist...

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Bibliographic Details
Main Authors: Jiawei Li, Yue Qiu, Long Li, Jiyan Wang, Yin Celeste Cheuk, Ruirui Sang, Yichen Jia, Jina Wang, Yi Zhang, Ruiming Rong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Medicine
Subjects:
renal IRI
DZNep
TIM-1
T cells
NF-κB
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.00305/full

Internet

https://www.frontiersin.org/article/10.3389/fmed.2020.00305/full

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