IGF1R and MAPK15 Emerge as Potential Targets of Pentabromobenzylisothioureas in Lung Neuroendocrine Neoplasms

IGF1R and MAPK15 Emerge as Potential Targets of Pentabromobenzylisothioureas in Lung Neuroendocrine Neoplasms

Pentabromobenzylisothioureas are antitumor agents with diverse properties, including the inhibition of MAPK15, IGF1R and PKD1 kinases. Their dysregulation has been implicated in the pathogenesis of several cancers, including bronchopulmonary neuroendocrine neoplasms (BP-NEN). The present study asses...

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Bibliographic Details
Main Authors: Ewelina Motylewska, Marcin Braun, Zygmunt Kazimierczuk, Hanna Ławnicka, Henryk Stępień
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Pharmaceuticals
Subjects:
bronchopulmonary neuroendocrine neoplasm
IGF1R
MAPK15
PKD1
ZKK
pentabromobenzylisothioureas
Online Access:https://www.mdpi.com/1424-8247/13/11/354

Internet

https://www.mdpi.com/1424-8247/13/11/354

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