Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination

Microglial aryl hydrocarbon receptor enhances phagocytic function via SYK and promotes remyelination in the cuprizone mouse model of demyelination

Highlights AhR regulates remyelination following cuprizone-induced demyelination. Deletion of AhR in adult microglia restrains efficient remyelination. Microglial AhR deficiency causes myelin debris accumulation and impairs phagocytic function. Microglial AhR mediates phagocytosis of microglia via S...

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Bibliographic Details
Main Authors: Yumeng Wang, Jingxian Sun, Keying Zhu, Danjie Wang, Xiaoqiang Zhao, Hongyu Zhang, Shuai Wu, Yanqing Wang, Jun Wang
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Neuroinflammation
Subjects:
AhR
Microglia
Phagocytosis
Remyelination
SYK
Online Access:https://doi.org/10.1186/s12974-023-02764-3

Internet

https://doi.org/10.1186/s12974-023-02764-3

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