The Tumour Suppressor Fhit Protein Activates C-Raf Ubiquitination and Degradation in Human Melanoma Cells by Interacting with Hsp90

The Tumour Suppressor Fhit Protein Activates C-Raf Ubiquitination and Degradation in Human Melanoma Cells by Interacting with Hsp90

Fhit protein expression is reduced in the majority of human tumors; moreover, its restoration both triggers apoptosis of cancer cells and suppresses tumor formation in a large number of preclinical models of cancers. In the following study, we observed that Fhit expression is significantly reduced i...

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Bibliographic Details
Main Authors: Francesco Paduano, Eugenio Gaudio, Francesco Trapasso
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomedicines
Subjects:
Fragile Histidine Triad Diadenosine Triphosphatase (<i>FHIT</i>)
heat shock protein 90 (Hsp90)
C-Raf
protein–protein interactions (PPIs)
melanoma
Online Access:https://www.mdpi.com/2227-9059/10/10/2551

Internet

https://www.mdpi.com/2227-9059/10/10/2551

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