Evaluation of whole genome sequencing utility in identifying driver alterations in cancer genome

Evaluation of whole genome sequencing utility in identifying driver alterations in cancer genome

Abstract In cancer genome analysis, identifying pathogenic alterations and assessing their effects on oncogenic processes is important. Although whole exome sequencing (WES) can effectively detect such changes, driver alterations could not be identified in 27.8% of the cases, according to a previous...

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Bibliographic Details
Main Authors: Takeshi Nagashima, Ken Yamaguchi, Kenichi Urakami, Yuji Shimoda, Sumiko Ohnami, Keiichi Ohshima, Tomoe Tanabe, Akane Naruoka, Fukumi Kamada, Masakuni Serizawa, Keiichi Hatakeyama, Shumpei Ohnami, Koji Maruyama, Tohru Mochizuki, Maki Mizuguchi, Akio Shiomi, Yasuhisa Ohde, Etsuro Bando, Teiichi Sugiura, Takashi Mukaigawa, Seiichiro Nishimura, Yasuyuki Hirashima, Koichi Mitsuya, Shusuke Yoshikawa, Yoshio Kiyohara, Yasuhiro Tsubosa, Hirohisa Katagiri, Masashi Niwakawa, Kaoru Takahashi, Hiroya Kashiwagi, Yoshichika Yasunaga, Yuji Ishida, Takashi Sugino, Hirotsugu Kenmotsu, Masanori Terashima, Mitsuru Takahashi, Katsuhiko Uesaka, Yasuto Akiyama
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Cancer genome analysis
Whole genome sequencing
Gene expression profiling
Driver alteration
Online Access:https://doi.org/10.1038/s41598-024-74272-0

Internet

https://doi.org/10.1038/s41598-024-74272-0

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