Encapsulation of Recombinant MOMP in Extended-Releasing PLGA 85:15 Nanoparticles Confer Protective Immunity Against a Chlamydia muridarum Genital Challenge and Re-Challenge

Encapsulation of Recombinant MOMP in Extended-Releasing PLGA 85:15 Nanoparticles Confer Protective Immunity Against a Chlamydia muridarum Genital Challenge and Re-Challenge

Recently we reported the immune-potentiating capacity of a Chlamydia nanovaccine (PLGA-rMOMP) comprising rMOMP (recombinant major outer membrane protein) encapsulated in extended-releasing PLGA [poly (D, L-lactide-co-glycolide) (85:15)] nanoparticles. Here we hypothesized that PLGA-rMOMP would bolst...

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Bibliographic Details
Main Authors: Rajnish Sahu, Saurabh Dixit, Richa Verma, Skyla A. Duncan, Lula Smith, Guillermo H. Giambartolomei, Shree R. Singh, Vida A. Dennis
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
Chlamydia muridarum
major outer membrane protein
nanovaccine
PLGA nanoparticles
neutralizing antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.660932/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.660932/full

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