Long non-coding RNA H19 regulates matrisome signature and impacts cell behavior on MSC-engineered extracellular matrices

Long non-coding RNA H19 regulates matrisome signature and impacts cell behavior on MSC-engineered extracellular matrices

Abstract Background The vast and promising class of long non-coding RNAs (lncRNAs) has been under investigation for distinct therapeutic applications. Nevertheless, their role as molecular drivers of bone regeneration remains poorly studied. The lncRNA H19 mediates osteogenic differentiation of Mese...

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Bibliographic Details
Main Authors: Sara Reis Moura, Jaime Freitas, Cláudia Ribeiro-Machado, Jorge Lopes, Nuno Neves, Helena Canhão, Ana Maria Rodrigues, Mário Adolfo Barbosa, Maria Inês Almeida
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Stem Cell Research & Therapy
Subjects:
Non-coding RNAs
Fragility fractures
Bone extracellular matrix
Gene therapy
Decellularization
Online Access:https://doi.org/10.1186/s13287-023-03250-6

Internet

https://doi.org/10.1186/s13287-023-03250-6

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