Direct Interaction of ATP7B and LC3B Proteins Suggests a Cooperative Role of Copper Transportation and Autophagy

Direct Interaction of ATP7B and LC3B Proteins Suggests a Cooperative Role of Copper Transportation and Autophagy

Macroautophagy/autophagy plays an important role in cellular copper clearance. The means by which the copper metabolism and autophagy pathways interact mechanistically is vastly unexplored. Dysfunctional ATP7B, a copper-transporting ATPase, is involved in the development of monogenic Wilson disease,...

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Bibliographic Details
Main Authors: Supansa Pantoom, Adam Pomorski, Katharina Huth, Christina Hund, Janine Petters, Artur Krężel, Andreas Hermann, Jan Lukas
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
Wilson disease
ATPase copper transporting beta
autophagosome-lysosome fusion
HepG2
LC3 interaction region
Online Access:https://www.mdpi.com/2073-4409/10/11/3118

Internet

https://www.mdpi.com/2073-4409/10/11/3118

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