Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis.

Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis.

Methicillin-resistant Staphylococcus aureus is estimated to cause more U.S. deaths annually than HIV/AIDS. The emergence of hypervirulent and multidrug-resistant strains has further amplified public health concern and accentuated the need for new classes of antibiotics. RNA degradation is a required...

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Bibliographic Details
Main Authors: Patrick D Olson, Lisa J Kuechenmeister, Kelsi L Anderson, Sonja Daily, Karen E Beenken, Christelle M Roux, Michelle L Reniere, Tami L Lewis, William J Weiss, Mark Pulse, Phung Nguyen, Jerry W Simecka, John M Morrison, Khalid Sayood, Oluwatoyin A Asojo, Mark S Smeltzer, Eric P Skaar, Paul M Dunman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21347352/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21347352/?tool=EBI

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