Repeated Exposure of Escherichia coli to High Ciprofloxacin Concentrations Selects gyrB Mutants That Show Fluoroquinolone-Specific Hyperpersistence

Repeated Exposure of Escherichia coli to High Ciprofloxacin Concentrations Selects gyrB Mutants That Show Fluoroquinolone-Specific Hyperpersistence

Recent studies have shown that not only resistance, but also tolerance/persistence levels can evolve rapidly in bacteria exposed to repeated antibiotic treatments. We used in vitro evolution to assess whether tolerant/hyperpersistent Escherichia coli ATCC25922 mutants could be selected under repeate...

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Bibliographic Details
Main Authors: Aurore Perault, Catherine Turlan, Nathalie Eynard, Quentin Vallé, Alain Bousquet-Mélou, Etienne Giraud
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Microbiology
Subjects:
experimental evolution
DNA gyrase
tolerance
persisters
quinolones
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.908296/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.908296/full

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