Induced Pluripotent Stem Cells to Model Juvenile Myelomonocytic Leukemia: New Perspectives for Preclinical Research

Induced Pluripotent Stem Cells to Model Juvenile Myelomonocytic Leukemia: New Perspectives for Preclinical Research

Juvenile myelomonocytic leukemia (JMML) is a malignant myeloproliferative disorder arising in infants and young children. The origin of this neoplasm is attributed to an early deregulation of the Ras signaling pathway in multipotent hematopoietic stem/progenitor cells. Since JMML is notoriously refr...

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Bibliographic Details
Main Authors: Zeinab Wehbe, Foued Ghanjati, Christian Flotho
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
JMML
leukemia
reprogramming
IPSC
differentiation
hematopoietic cells
Online Access:https://www.mdpi.com/2073-4409/10/9/2335

Internet

https://www.mdpi.com/2073-4409/10/9/2335

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